9/16/2023 0 Comments Selective sweepHe suggested bad mutations are very common, which we know is true of course. Well, in response to this an alternative hypothesis was posed by this fellow, this is professor Brian Charlesworth at the University of Edinburgh in Scotland. Well, if that's true, then you won't actually see a very strong overall trend, because you'll actually have a lot of low recombination regions that may still have very high pi, right? If you're not having a selective sweep that's eliminating the neutral variation there, they might sustain a fairly high pi. Now, the question is, what if beneficial mutations are actually very rare? Not just somewhat rare, but very rare. Now, again, their ideas that there's very frequent selective sweeps on the genome and that's what causes this overall positive association. Chip Aquadro's at Cornell, David Begun's at now at the University of California at Davis. This was pioneered by these two fellas, David Begun and Chip Aquadro. I already gave you the positive view of the world, this idea that official mutations around the genome cause this association between the recombination and pi, this spread of adaptive variance. Now, background selection is an alternative explanation for this pattern, and this is a continuing heated debate within the field of evolutionary biology in terms of its role relative to the other one. Reduces little variation has higher recombination, making them so they can sustain high pi. This reduces a lot of variation in regions of low recombination, making it so they have low pi. We suggested that one possible explanation for why there's this positive association between recombination rate and pi just because you have frequent selective sweeps across the genome. In the previous video we talked about this association between recombination rate and the pi overall. Hello, welcome back to introduction to introduction of genetics and evolution.
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